Well, I guess I will throw my two cents in! I bought my 2017 DRW Mega-Cab 4x4 with the Aisin and 3.73's last April. I live in Monument CO which sits between Denver and Colorado Springs at about 7300 feet of elevation. My truck now has a touch over 30,000 miles, probably 75% or better towing our 15,000 39 foot fifth wheel...we are now "full timers". Our travels take us out to CA to Sacremento and Napa Valley, down to Bakersfield and Blythe, over to AZ to Phoenix and Tucson, back up to Monument, over to Tulsa and as I write this, I am sitting in an RV park in Panama City, Florida. I write the above, just to give some background for my following thoughts on what constitutes the "ideal" gear ratio.
I should mention that while I have driven pickup trucks my entire adult life and have towed stock trailers as well as travel trailers for over 30 years, I am no mechanic nor professional driver and certainly no expert!
But I have come to the conclusion that it simply comes down to how fast one tows/drives. I drive empty at 65-70 mph and I tow around 65-68. If I wanted to zip along at 80 mph and did that often, the 3.42's would really shine! If I towed at 55-60 mph (as we must in CA) then the 4.10's would be ideal....but I do neither! For MY speeds, the 3.73's are a great middle ground...or "compromise" if you must. I don't mind a "compromise" when it is beneficial to me! The more I drive and tow the more I consider the 4.10's...because I don't always feel comfortable towing at 68 and I am in the mountains a lot and I AM getting older! (63 as I sit!) if I were running empty between LA and Phoenix, the 3.42's would be great! But those days are behind me and probably not returning!
I think it is obvious that all three set ups will work...but since we have the chance to drive the perfect tow beast, you might as well tune your ride to your driving habits.
As an aside, the travel blog "Roads Less Traveled" has a great article on the process they took (2 years!) to get their perfect tow beast...and they have a lot of great articles about their 10 years of full time travels.....I've never met the authored and have NO relationship with them....but great reads"