az,
I've done it a couple times -- not an expert but here's my best hints.
Drain some fuel out by pushing up the water-in-fuel sensor assembly. Then unscrew the water-in-fuel sensor assembly (disconnect the wiring first). I was able to maneuver an oil filter strap wrench onto the filter to unscrew it -- not easy but it can be done. There are a couple gaskets that are used -- look at the old filter to see where they go. Some guys say don't put in any fuel in the new filter because it could introduce contamination. I don't know if that's true; it depends on which way the fuel flows through the filter. In any case, I fill it about halfway full before installing it. Restart the filter on the filter head and tighten snugly with the strap wrench. Reattach the water-in-fuel assembly and connect the wiring.
If you can find the plunger on the lift pump, push it repeatedly to prime the system. Otherwise, use the starter (be careful not to crank the starter more than 30 seconds).
I'm sure you will get other ideas but this is my $. 02
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1996 Dodge 2500 4X4 SC, SLT, Cummins 12V, 5-spd. , JRE 4" exhaust (my kitty ran away into the woods and the muffler fell off!), TST 280 HP/685 Ft-Lb Uprate Kit, AFC Spring Kit, Horton Fan Clutch, Jacobs/Ram Exhaust Brake, MagHytec Differential Cover, Prime-Loc, Rancho RS9000 Shocks, Combo Gauge, K&N Air Filter, Brite-Box, Geno's finger-touch oil pan drain plug, Optima Yellow Tops, no turbo silencer ring, full-time fog lights.