I-40 through LittleRock is bad, especially if you hit it at rush-hour. "Trucks" are restricted to the right lane and the lanes are narrow, with the big concrete barricades. East of Littlerock, there is one or 2 places where it goes to one lane, and there is a stretch that is rough. I say "1 or 2" because I have been through there 6 times since early December, and the construction zones keep changing!
When you hit Memphis, stay in the LEFT lane after you cross the Mississippi River bridge. Beware of the sharp curve and barricades going thru the construction to get onto I40/240. After you are on 240, keep to the middle or right lanes until you pass the split for the Millington exit (I forget the hwy #), then take the far left lane again for the left-lane exit to I-40 East . . then you're out of the Memphis confusion. At any of these 3 interchanges, if you are in the wrong lane, you're hosed!