I have just over 114K on mine and purchased the truck new in August, 2004.
Right off the bat, I purchased a Banks 6-gun w/speed loader and was in heaven. I ran the Banks till 72K miles and mostly had it on 3; when playing, I'd put it on 5 or 6. From 72K till now, I've ran a Smarty S0-6 on setting 5.
I also have the GDP's 2 micron filter kit installed.
Over the last couple of months and 2K miles, my truck would idle erratically every now and then and puff blue smoke on start-up; at times worse than others. After much research, I settled on changing out the injectors.
After reading issue 72 Technical Topics (injectors) by Joe Donnelly, I decided to purchase a set of DDP stage 1's and have them installed. I wanted to get more of a mechanical increase in power and hopefully some mileage increases as a side effect.
I've driven the truck two days now and have noticed that it runs very nice, definitely more power than stock. I'm NOT running the Smarty now and may decide to sell it.
What I have noticed though is that the EGT's are higher.
Basically, what many guys here say is that if you leave your truck stock, you should get plenty of miles out of your injectors. Run power enhancements, and you run the risk of pre-mature injector failure.
Oh, and on edit, the cost of replacing them WASN'T AT ALL worth the "fun" I had with the truck. Money would have been better spent elsewhere.