Your front driveshaft slip joint will last longer if you leave them locked in. But it is a lot cheaper than front differential parts. In short though, you'll pay a little extra for fuel. It will be much more convenient to use 4x4. I always left mine unlocked, usually until it meant I was wading out there and reaching down in the mud to lock them in. I had a 1958 Apache 3/4 ton that I drove way too many miles. It had the Birfield (SP) axles, a heavy ball and socket with seven bearings for the drive force instead of a big U-joint. I ran it enough that the bearings wore a groove in the knuckle, it made all kinds of nasty clicking noises when turning in four wheel drive. The front axle assembly never broke, in spite of my youthful ignorance and abuse. It would however beat the driveshaft slip joint out about every 50 to 75 thousand miles. That particular truck was a NAPCO conversion and the transfer case was divorced from the transmission. The front drive shaft was extremely long and bouncing down the road with the front end unlocked, it would beat the slip joint to death. Engage it when you think you might need it, leave it unlocked the reat of the time and it will probably outlive the rest of the truck. Unless you are trying to pull something in reverse, the rear axle still does most of the work. A Dana 60 is a very strong unit. Glen