I think twins will provide a huge amount of versatility that you can't expect from a large single. I know that a couple fella's are having good results with a larger single but I think that the fueling limits of the VE will still require a set of dual huffers in the end.
Right now, my fuel settings are no were near maxed and I can hit 1550 - 1600*F at 45psi in no time. In fact, I pull out of it at that point choosing not to let it run higher.
There are a few of us who have far more fuel than can be burned effectively with a single hybrid charger.
You can forestall the need for twins by going with good air enhancements like porting, ATS, Port/Polish head, cam etc.
bob... .