Couple of things could be wrong. The most likely is the sprag clutch in the TC stator has locked up. Does it run ok once you get up to about 25 mph, shifts fine up and down after that, no stack shifting or early shifts? If so time for a new TC.
If you have early shifting, sticking in gears or stack shifting into OD could be an issue with the lockup and OD solenoids or the transmission pump.