Man, I shouldn't even be mentioned in the same sentence as those guys. There's plenty of people more knowledgeable than me around here.
Regarding the S300-400-500 setup, I don't know anyone that has tried that, but I don't think it would be optimal for spoolup. First, the flow would be very uneven, since your larger turbo would no doubt have a much larger exhaust housing and bigger turbine wheel/heavier comp wheel/etc. Second, the way twins spool is complex, but a large part of spoolup time is based on how fast the secondary stage (manifold charger) spools. You'll only have 3 cylinders feeding an S300 secondary, and another 3 feeding a 400. You wouldn't have enough airflow to light 'em before 3k, I bet.
If you want to run two different-sized chargers in parallel on the hot side, you're going to be giving up most of the advantagee of that extra stage of compounding you just added. I think it is potentially possible, but just don't know enough to say for sure. You could set up a wastegate on the 300 to dump over into the 400, but that wouldn't get your spoolup all back.
You could run a pair of small S200's on the manifold and a big S400 below them if you're wanting to run two turbos in parallel, though.
The easiest way to think about twins is this: You have a 359cid diesel you're trying to feed with your manifold charger, so size it appropriately. Let's say we use an S300. If we want to add another stage of turbocharging, we look at the system as a whole now. Our 359cid engine on x amount of boost requires the airflow of a naturally aspirated yyy cid engine. Let's say it's equivalent to 800 cid. Now we size our next stage of charger based on those requirements. And so on for however many stages you're adding.
The problem with triples is that by the time anyone gets to the stage where they need that kind of power, they don't care about spoolup anymore, so there's no use keeping the littlest stage. Look at the pro mod pullers - they're running top chargers bigger than Big Brothers because spoolup is not an issue, and their engine/head/cam/pump setups reflect the same thinking.
Chris