I havent been quite as fortunate... My 06 is stock with 40K on it and has had the blend doors fall of twice now, once under warranty, and once again NOT under warranty. The transmission hasn't failed on me, but half the time it can't decide whether it wants 1st of 2nd gear, so it oscilates back and forth between the two until you hit it with about 15 psi of boost. . The dealer couldnt/wouldn't fix it. . It WILL have Goerend parts in it one day soon.
Had to have the steering/suspension update performed. Also had some issues with the interior lights powering down after 15 seconds... Front axle seals blew at 28K miles.
I love my truck, the engine itself has been flawless. While my truck may get worked hard from time to time, I maintain it all myself to my own standards (which are way higher than ANY dealership or shop) It gets nothing but the best fluids, filters, greases, wax, etc...
Its not a perfect design, but it is definitely better than the competition in that year and better than all of them now IMO... (Not a fan of the regen diesels. . )
If you know the weaknesses, there are aftermarket parts to fix most anything. I believe many on here have installed aftermarket suspension components. Of course, Goerend can fix any transmission issues, heatertreater can fix the blend door issues. .