I was considering the FX45 to replace my wife's current ride, a 2000 Lexus LX470. Did not like the lack of space behind the rear seat to haul groceries, plus we have two kids. If only you and your wife, you could load up the rear seats for shopping and be good to go. Performance is real good. I've driven the Lexus RX330 and like that SUV a lot. My brother has a Toyota Highlander, similar to the Lexus RX and his likes it, his wife loves it.
In the end, we kept the LX470. My wife really loves that vehicle, plus it is close to being paid for.