I am speaking from a little experience when using a tuner/programmer (Smarty S67) and towing a 5er. Do not expect any big mileage improvements when towing. I have over 11 years of data with the first year as stock to set a baseline. I towed my 5er a 2006 Summit Ridge Ameri-Camp in 2008 with the stock engine, my fuel mileage was between 9 and 10 MPG's. I deleted in 2009 and became my own warranty station, my towing fuel mileage with the same trailer was now between 10 and 11 MPGs.
I have since upgraded to a different camper a 2016 Cedar Creek 34RL, which is like towing anchor behind the truck do to the wind resistance (13'-6" tall). My fuel mileage over four years of ownership (purchased new in 2015) varies between a low of 8.5 (40 MPH headwind) to a high of 12 MPG's. Mainly the fuel mileage is around around 10 to 11 MPG's.
With your truck and the SCR system on it, I would leave it stock unless you want to spend an additional $1,000 to $2,0000 to gain about 2 miles per gallon improvement.