It depends largely upon your driving habits, but to some degree: Yes.
I've had Chevys with Detroit Lockers and with factory eaton Gov-Lok lockers. 90% of the time they were completely transparent. But every now and then (and I'm talking once every few months), BANG! , and I swore I just left a trail of differential parts strewn behind me, but I never did. Incidently, both lockers worked great and I never broke either of them or an axle shaft or anything else.
The Powertrax I have not tried, but I did speak to a very straight-talking Richmond tech rep just a few days ago about one I just bought. There is no getting away from the occasional release and relock jolt completely. But not powering hard through corners will help with any locker. He said the Powertrax is softer in its engagement and release than the Detroit, but still a locker and it will bang now and then, but it is nothing to worry about.
In my experience, you definitely want to keep your tires the same size and inflated exactly the same, too, or a locker will pull the truck to one side when you accelerate and exacerbate the locking/unlocking noise in corners, too.
I'll be putting a Powertrax in my Dana 80 as soon as I locate a factory open carrier to replace my factory "un"limited slip carrier. I will learn all about them then.