Bush Whacker, DF,
From what I've been told drive <= boost is nirvana anywhere above 20-30 psi of boost. Less than boost being a realtively small amount. . 1-5 psi for instance at 60+ psi and be sure EGTs are in check.
Powerstrokes run 1. 5:1 on a regular basis. CTDs do too when turned up a bit.
The real trick is to keep drive pressure and EGTs down at the same time. getting drive pressure down can be done with a bigger housing but how much fuel can you burn at 50psi of boost and still keep egts in line? You will reach a HP level with a turbo and intake system after which some other power adder is necessary to keep EGTs down. Water/Alcohol injection, Nitrous, or something of the like to either add oxygen to the mix or get the temps down and make the charge denser.
On a single, >40psi makes compressor outlet temps soar. partly due to the heat of compression then the increasing lack of efficiency of the compressor.
Compund turbos combat temps on volume and tempreature. If properly tuned both compressors will stay in the efficient part of the map so all you have to deal with (for simplicity's sake) is the heat of compression. Hopefully the turbos won't add any unneccessary heat.
The heat generated by compressing 1000+ cfm of air to 60 or 80 psi is immense and the cooling systems on our trucks will become heat soaked in short fashion, limiting the duration of sustained extemely high hp exertions. EGTs don't rise much but coolant temps do.
FWIW,
Mark