168,000 miles on an 01 3500 quad cab 4x4 w/6spd.
Bought it used with 101,000 in July of 05. She had just had the brakes done. All I have changed is the APPS sensor. Still ran, just couldn't use the cruise control due to losing throttle response when you took it off cruise. It still has the original clutch.
I have a 150 mile round trip commute everyday. 750 a week, 39,000 a year - on the low end. I did almost 50,000 last year. I average 18+ mpg now, 21. 5 when I had a flatter commute. I am moving down to The Vegas area, and have been doing a lot of towing of heavy trailers ,as I bring all of my machinery down here. No complaints here-I am never going back to a gas truck again.