Should be no problem at all. Just use a high quality gear oil that's been mentioned in some posts already. Also overfill by a liter or 2 to help keep things lubricated.
I use Swepco 80w-90 gear oil in my transmission and love it a lot. This oil is limited in dealer distribution so whatever oil TDR members think is the best should also work very well.
I tow heavy loads quite a bit, run many dyno pulls, sled pulling, and drag racing. The only thing that has failed was my stock clutch which blew to pieces. While transmission was out for clutch replacement, it was opened and inspected for shaft play etc, and all was still good and tight. Even the 5th gear was solid.
Scott Vorhees' 1997 Big Bad Dodge sled puller ran a nv4500 with almost 1,000 hp. These trannies have got to be reliable enough for Scott to win many first, second places etc as they have to collect points over the pulling season.
The nv5600 is a good transmission and can be made reliable as well with good oil and overfilling too.
For me the nv4500 just cost less and worked fine.
Shawn